In a mutant failing pit specification, neither are biased due to an inactive pit. Supporting this, junctional myosin is enriched in, and neighbour exchanges are biased towards the circumferential orientation. Further from the pit cells interleave circumferentially, suggesting apically driven behaviours. Extending analyses in 3D, we find that near the pit of invagination, isotropic apical constriction leads to strong cell-wedging. Using live-imaging and novel morphometric methods, we show that in addition to apical constriction, radially oriented directional intercalation of cells plays a major contribution to early stages of invagination of the salivary gland tube in the Drosophila embryo. Cell behaviours that drive such processes are only starting to be unraveled. The budding of tubular organs from flat epithelial sheets is a vital morphogenetic process.
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